医学博士(第四军医大学)
生物学硕士(陕西师范大学)
生物技术学士(陕西师范大学)
新疆医科大学基础医学院生物化学与分子生物学教研室,副教授。主持国家自然科学基金一项,自治区自然科学基金2项,参与国家自然科学基金十余项,共计发表SCI论文30余篇,其中一作或共同一作SCI文章7篇,JCR一区4篇,二区2篇,三区1篇。课题组主要关注白癜风等皮肤病的发病机制及防治策略研究。围绕白癜风的发病机制,从遗传、环境、免疫等方面入手,利用分子生物学、细胞生物学、免疫学等手段技术深入分析了白癜风发病各个环节的关键机制,寻找白癜风治疗可能的作用靶点。
主要承担或参与的课题
1. HSP70-HSF1-Atg5/Atg12通路调控自噬:白癜风黑素细胞氧化损伤的新机制,2017.1,国家自然科学基金青年项目,81703128,主持
2. ROS介导的黑素细胞糖代谢异常在白癜风发生发展中的作用及机制研究,自治区“天池博士”项目,2023.1,主持
3. 黑素细胞铁死亡在白癜风发病中的作用和机制研究,2022.12,自治区自然科学基金杰出青年项目,2022D01E52,主持
4. 角质形成细胞重编程在白癜风发病中的作用机制,国家自然科学基金重点项目,2019-01,81930087,参与
5. 皮肤Treg细胞在白癜风发病中的作用及表观遗传调控机制研究,国家自然科学基金重大研究计划重点支持项目,2018.1,91742201,参与
近期发表的主要文章
1. Jianru Chen#, Xinju Wang#,Tingting Cui#, Qingrong Ni, Qian Zhang, Daopei Zou, Kaiqiao He, Wei Wu, Jingjing Ma, Yinghan Wang, Weinan Guo, Chunying Li*, Shuli Li*.Th1-like Treg in vitiligo: An incompetent regulator in immune tolerance. J Autoimmun, 2022 Jul 2;131:102859.(JCR 1区,IF=14.1)
2. Tingting Cui#, Yinghan Wang#, Jiaxi Chen, Xiuli Yi, Pan Kang, Sen Guo, Shuli Li, Kai Li, Chunying Li*. HSF1 dependent autophagy activation contribute to oxidative-stress induced melanocyte destruction in vitiligo. J Invest Dermatol,2021 Nov 13; S0022-202X(21)02488-X (JCR 1区, Top, IF=8.4)
3. Tingting Cui#, Weigang Zhang#, Shuli Li, Jiaxi Chen, Yuqian Chang, Xiuli Yi, Pan Kang, Yuqi Yang, Jiaxi Chen, Ling Liu, Zhe Jian, Kai Li, Gang Wang, Tianwen Gao, Pu Song *, Chunying Li *. Oxidative stress-induced HMGB1 release from melanocytes: a paracrine mechanism underlying the cutaneous inflammation in vitiligo. J Invest Dermatol, 2019,139(10):2174-2184 (JCR 1区, Top, IF=7.143)
4. Qian Zhang#,Tingting Cui#, Yuqian Chang, Weigang Zhang, Shuli Li, Yuanmin He, Bing Li, Ling Liu, Gang Wang, Tianwen Gao, Chunying Li*, Zhe Jian*. HO-1 regulates the function of Treg: Association with the immune intolerance in vitiligo. J Cell Mol Med, 2018, 22(9):4335-4343(JCR 2区,IF=4.658)
5. Xiuli Yi#,Tingting Cui#, Shuli Li, Yuqi Yang, Jiaxi Chen, Sen Guo, Zhe Jian, Chunying Li, Tianwen Gao, Ling Liu*, Kai Li*. Identification of the Risk HLA-A Alleles and Autoantigen in Han Chinese Vitiligo Patients and the Association of CD8+T Cell Reactivity with Disease Characteristics. Med Sci Monit, 2018, 16;24:6489-6497 (JCR 3区,IF=1.98)
6. Tingting Cui#, Xiuli Yi#, Sen Guo, Fubo Zhou, Ling Liu, Chunying Li, Kai Li* & Tianwen Gao. Identification of Novel HLA-A*0201-Restricted CTL Epitopes in Chinese Vitiligo Patients. Sci Rep, 2016,6:36360 (JCR 1区,IF=4.02)
7. Tingting Cui #, Xiuli Yi#, Weigang Zhang#, Chao Wei, Fubo Zhou, Zhe Jian, Gang Wang, Tianwen Gao, Chunying Li*, Kai Li *. miR-196a-2 rs11614913 polymorphism is associated with vitiligo by affecting heterodimeric molecular complexes of Tyr and Tyrp1. Arch Dermatol Res, 2015,307(8):683-692(JCR 2区,IF=2.3)
研究生与博士后培养、专职科研人员招聘
1. 硕士研究生
2. 专职科研人员:有志于从事基础科学研究的本科及硕士毕业生。